在与红骷髅的殊死决斗后,美国队长(克里斯·埃文斯 Chris Evans 饰)驾驶着失控的飞机坠毁在茫茫冰原之上。最后的关头,他向佩吉·卡特(海莉·阿特维尔 Hayley Atwell 饰)告别,彼此生死相别。一年后,佩吉被安排在清冷的部门,完全不受重用。虽然她向上司自荐,怎奈对方完全不拿她当回事儿。某天晚上,佩吉被留在办公室加班,这时电话响起,对方说已经锁定十二宫的位置,对方携带杀伤力强大的武器,请求特工局派出探员支持。佩吉没有报告上司,而是独自一人前往目的地。 夜幕之下,这位果敢女子勇闯虎穴……A year after Captain America was lost in action, the war is over. However, Agent Peggy Carter is relegated to a desk job and frustrated at her male boss and comrades' sexist dismissal of her place in the SSR. Ordered to work late one night, Carter gets an alert that the villain, Zodiac, has been spotted. Deciding to take care of it herself, Carter is ready to show the enemies of peace why meeting this Agent 13 is bad luck for them.