美国德克萨斯州乡村,老牛仔Moss(乔什·布洛林 饰)在猎杀羚羊时发现几具尸体,几包海洛因和200万现金。Moss决定将毒品和现金占为己有,想以此改变自己的生活,谁知却遭到冷血杀手Chigurh(哈维尔·巴登 饰)的跟踪和追杀,陷入了逃亡的险境。 同时,当地治安官Bell(汤米·李·琼斯 饰)也在对一连串的杀人事件进行调查,并努力保护Moss的安全。但是,让Bell感到无力绝望的是,他使尽浑身解数也无法追踪到冷血杀手,Moss的生命安全也受到严重的威胁,Bell一边缅怀父辈们的光荣岁月,一边深感现实中老无所依的悲哀。In rural Texas, welder and hunter Llewelyn Moss (Josh Brolin) discovers the remains of several drug runners who have all killed each other in an exchange gone violently wrong. Rather than report the discovery to the police, Moss decides to simply take the two million dollars present for himself. This puts the psychopathic killer, Anton Chigurh (Javier Bardem), on his trail as he dispassionately murders nearly every rival, bystander and even employer in his pursuit of his quarry and the money. As Moss desperately attempts to keep one step ahead, the blood from this hunt begins to flow behind him with relentlessly growing intensity as Chigurh closes in. Meanwhile, the laconic Sherrif Ed Tom Bell (Tommy Lee Jones) blithely oversees the investigation even as he struggles to face the sheer enormity of the crimes he is attempting to thwart.