喜剧演员杰克(威尔•法瑞尔 Will Ferrell 饰)事业开始下滑,在经纪人的建议下,杰克准备翻拍经典搞笑连续剧《神仙俏女巫》。同时,为了巩固自己在该剧的地位,杰克必须找一名新人在他的剧集里演他的妻子,女巫萨曼纱。在面试了数百人后,迷人可爱而且还会和女巫一样耸鼻子的伊莎贝拉(妮可•基德曼 Nicole Kidman 饰)进入了杰克的视线。在杰克鼓动了自己的三寸不烂之舌后,伊莎贝拉终于同意和他一起出演该剧。 该剧试播后反响强烈,为了和伊莎贝拉长久合作下去,杰克决定假戏真做,向伊莎贝拉展开了爱情攻势。只是,他有所不知道是,伊莎贝拉真的是一名法力高强的女巫,杰克以后的日子可不好过了。Out in California's San Fernando Valley, Isabel is trying to reinvent herself. A naïve, good-natured witch, she is determined to disavow her supernatural powers and lead a normal life. At the same time, across town, Jack Wyatt a tall, charming actor is trying to get his career back on track. He sets his sights on an updated version of the beloved 1960s situation comedy Bewitched, re-conceived as a starring vehicle for himself in the role of the mere-mortal Darrin. Fate steps in when Jack accidentally runs into Isabel. He is immediately attracted to her and her nose, which bears an uncanny resemblance to the nose of Elizabeth Montgomery, who played Samantha in the original TV version of Bewitched. He becomes convinced she could play the witch Samantha in his new series. Isabel is also taken with Jack, seeing him as the quintessential mortal man with whom she can settle down and lead the normal life she so desires. It turns out they're both right--but in ways neither of them ever imagined.