人迹罕至的森林中,四个乘舟沿河漂流的年轻人被一名畸形的食人猎手袭击,食人狂用弓箭和陷阱将他们猎杀殆尽,只有一名名叫爱丽丝(Janet Montgomery 饰)的姑娘侥幸逃脱。几乎与此同时,西弗吉尼亚州的葛夫顿监狱中,狱警尼特(Tom Frederic 饰)和搭档接到了一项任务:将墨西哥裔犯人查韦斯(Tamer Hassan 饰)等人转移到另一所监狱。为了防止查韦斯的同伙于路劫车,监狱安排卧底乔装成犯人与查韦斯同行,然而意外还是发生了,囚车在荒凉的山路上被食人狂驾驶的车子撞下悬崖…… 囚犯们夺走枪支反客为主,尼特因为熟悉地形而担任向导,大难不死的爱丽丝出现在这支混合囚犯与狱警的队伍前面,她带来了食人狂的信息,夜色深锁的密林中,疯狂而又漫长的一夜刚刚才开始……While rafting in the Bluefish River area, four college kids are attacked by the mutant cannibal hillbilly Three Finger. Only the teenager Alex succeeds in escaping running through the woods. Meanwhile, a group of dangerous criminals are transported from the West Virginia Grafton Penitentiary in a custody bus escorted by three security guards through the backwoods. When they park in a rest stop in a police station, Sheriff Carver is informed about the missing teenagers. The bus driver heads to their destination with the guards and the prisoners but a tow truck driven by Three Finger hits the bus that falls off the road. They are attacked by Three Finger and the perilous Carlo Chavez dominates the guards and the other prisoners. When they accidentally meet Alex, the girl tells how sick and threatening Three Finger is; sooner the survivals discover that Alex is telling the truth.