炼金术,一种建立在等价交换原则基础上的科学,将物质进行理解、分解、再构造,将一种物品变成另外一种。但是,这样先进的技术却不能进行人体炼成,这是炼金术绝对的禁忌。可是,拥有极高炼金术天赋的爱德华(朴璐美 配音)和阿尔冯斯(钉宫理恵 配音)兄弟,因为对母亲极大的思念不惜触犯禁忌。而最终的代价却是,爱德华失去了一条手臂和一条腿,弟弟阿尔冯斯只能将灵魂依附在一副巨大的装甲之内。终于明白一切的兄弟俩,为了恢复原状,寻求更多的炼金术知识,成为国家炼金术师踏上了寻找终极炼金物品——贤者之石的旅程。在不断的探索中,两兄弟终于发现了贤者之石背后的真相,对身处的这个军事化国家也有了更深入的了解。此时,面对国家、民族、家庭……炼金术的未来究竟在何处。Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.