伯特·法兰德（约翰·卡拉辛斯基 John Krasinski 饰）和维罗纳·德·泰桑特（玛娅·鲁道夫 Maya Rudolph 饰）是一对恩爱夫妇，维罗纳怀孕了，因此二人需要找到一个最适合的地方，安家，抚育即将到来的子女。他们首先想到投奔伯特父母，却不巧遇上二老决定出门旅行，他们继续走过亚利桑那州、威斯康辛州，寻找许多故交、亲属，也目睹家家有本难念的经。在走过一站又一站的过程中，两个人的感情愈发相笃，愈加意识到彼此都是唯一，也许将来也会遇到所见其他夫妻那样的问题，也正是这些真实故事，更利于他们找到幸福，兜兜转转，他们最终的家到底在何方……Burt Farlander and Verona De Tessant are a couple steeped in eccentricity and irregularity but are very much in love. So when they find out that Verona is pregnant they seem to be taking it in their stride. Verona is enjoying pregnancy, Burt is already practicing skill that he believes a good father should have, and they living in the same state as Burt's parents, Jerry and Gloria, so that their prospective daughter can have grandparents. However, things are shaken up when Burt and Verona go to dinner at Jerry and Gloria's house, as Burt's parents reveal a surprising piece of news. They have decided to move to Antwerp in Belguim a month before the baby is due, scuppering Burt and Verona's plans of having their children's grandparents around. Because Verona lost her parents when she was relatively young, she finds this news very hard to take, but the resilient couple quickly find a way to turn it in to a positive. It becomes obvious that this is what the pair needed, as they decide to embark on a search for the right place for them to raise their daughter. They go to every place they can think of, meeting family and friends along the way, with laughter and sadness, this is a road trip the couple will never forget.
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