电影讲述了外星共生体“毒液”与宿主埃迪(汤姆·哈迪 饰)这对“最佳拍档”遇上致命反派共生体“卡内奇”(伍迪·哈里森 饰),超级英雄和邪恶反派的宿命之战即将开始。Eddie Brock attempts to reignite his career by interviewing serial killer Cletus Kasady, who becomes the host of the symbiote Carnage and escapes prison after a failed execution.