该剧根据Beth Macy撰写的同名畅销书改编,迈克尔·基顿扮演老派医生塞缪尔·芬尼克斯,他以仁慈和同情心对待自己的工作,但他发现自己陷入了大制药公司致命的秘密之中。The series takes viewers to the epicenter of America's struggle with opioid addiction, from the boardrooms of Purdue Pharma, to a distressed Virginia mining community, to the hallways of the DEA.