警探探戈及加什，行动勇猛，办案搏命，在某项行动中，破获庞大白粉走私案，黑帮损失极大，于是设下圈套，令二探员成为杀人凶手，被判入狱。黑帮又买通狱长，要玩残两人，两人只有逃狱。往找黑帮晦气，及找出证据证实二人无辜！Ray Tango and Gabriel Cash are narcotics detectives who, while both being extremely successful, can't stand each other. Crime Lord Yves Perret, furious at the loss of income that Tango and Cash have caused him, frames the two for murder. Caught with the murder weapon at the scene of the crime, the two have no alibi. Thrown into prison with most of the criminals they helped convict, it appears that they are going to have to trust each other if they are to clear their names and catch the evil Perret.
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